This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]
A: Control group, 14 days
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Consequently, mitochondria are of great importance for connecting oxidative stress and aging, making them a key target for therapeutic interventions aimed at mitigating age-related diseases
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